MODIFICATION OF SARCOLEMMAL Na-K ATPASE AND Na-Ca EXCHANGER EXPRESSION IN HEART FAILURE BY BLOCKADE OF RENIN-ANGIOTENSIN SYSTEM
نویسندگان
چکیده
Qiming Shao, Bin Ren, Vijayan Elimban, Paramjit S. Tappia, Nobuakira Takeda, and Naranjan S. Dhalla Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre and Departments of Physiology, Faculty of Medicine; Human Nutritional Sciences, Faculty of Human Ecology, University of Manitoba, Winnipeg, Canada; and Aoto Hospital, Department of Internal Medicine, Jikei University, Tokyo, Japan
منابع مشابه
Modification of sarcolemmal Na+-K+-ATPase and Na+/Ca2+ exchanger expression in heart failure by blockade of renin-angiotensin system.
The activities of both sarcolemmal (SL) Na(+)-K(+)-ATPase and Na(+)/Ca(2+) exchanger, which maintain the intracellular cation homeostasis, have been shown to be depressed in heart failure due to myocardial infarction (MI). Because the renin-angiotensin system (RAS) is activated in heart failure, this study tested the hypothesis that attenuation of cardiac SL changes in congestive heart failure ...
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تاریخ انتشار 2005